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Yeh-Long Chen Selected Research

quinoline

5/2020DFIQ, a Novel Quinoline Derivative, Shows Anticancer Potential by Inducing Apoptosis and Autophagy in NSCLC Cell and In Vivo Zebrafish Xenograft Models.
1/2019Pharmacological inhibition of bacterial β-glucuronidase prevents irinotecan-induced diarrhea without impairing its antitumor efficacy in vivo.
11/2017Specific Inhibition of Bacterial β-Glucuronidase by Pyrazolo[4,3-c]quinoline Derivatives via a pH-Dependent Manner To Suppress Chemotherapy-Induced Intestinal Toxicity.
6/2017Discovery of Indeno[1,2-c]quinoline Derivatives as Potent Dual Antituberculosis and Anti-Inflammatory Agents.
1/20179-bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-11H-indeno[1, 2-c]quinolin-11-one (BPIQ), A Quinoline Derivative Inhibits Human Hepatocellular Carcinoma Cells by Inducing ER Stress and Apoptosis.
1/2017Dual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ-induced apoptosis and anti-migration of human non-small cell lung cancer cells.
8/2016TCH1036, a indeno[1,2-c]quinoline derivative, potentially inhibited the growth of human brain malignant glioma (GBM) 8401 cells via suppression of the expression of Suv39h1 and PARP.
4/2016Quinoline-Based Compound BPIQ Exerts Anti-Proliferative Effects on Human Retinoblastoma Cells via Modulating Intracellular Reactive Oxygen Species.
12/2015BPIQ, a novel synthetic quinoline derivative, inhibits growth and induces mitochondrial apoptosis of lung cancer cells in vitro and in zebrafish xenograft model.
1/2015Discovery of 2-[2-(5-nitrofuran-2-yl)vinyl]quinoline derivatives as a novel type of antimetastatic agents.
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Yeh-Long Chen Research Topics

Disease

39Neoplasms (Cancer)
01/2022 - 10/2002
8Breast Neoplasms (Breast Cancer)
08/2016 - 02/2010
6Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
02/2019 - 03/2008
5Hepatocellular Carcinoma (Hepatoma)
01/2021 - 11/2005
4Prostatic Neoplasms (Prostate Cancer)
11/2018 - 03/2008
4Leukemia
12/2012 - 10/2007
4Carcinoma (Carcinomatosis)
01/2012 - 11/2005
3Liver Neoplasms (Liver Cancer)
01/2021 - 12/2012
3Neoplasm Metastasis (Metastasis)
01/2015 - 08/2009
3Squamous Cell Carcinoma of Head and Neck
06/2010 - 11/2005
2Colorectal Neoplasms (Colorectal Cancer)
01/2022 - 01/2019
2Diarrhea
01/2019 - 11/2017
2Lung Neoplasms (Lung Cancer)
12/2015 - 07/2011
2Polyploidy
04/2013 - 03/2008
2Sepsis (Septicemia)
05/2012 - 09/2009
2Adenocarcinoma
01/2012 - 03/2008
2Adenocarcinoma of Lung
01/2010 - 09/2009
1Dysbiosis
01/2022
1Carcinogenesis
01/2022
1Malaria
05/2020
1Bacteriuria
05/2020
1Arthritis (Polyarthritis)
01/2019
1Psoriasis (Pustulosis Palmaris et Plantaris)
10/2018
1Drug-Related Side Effects and Adverse Reactions
11/2017
1Tuberculosis (Tuberculoses)
06/2017
1Glioma (Gliomas)
08/2016
1Retinoblastoma (Glioblastoma, Retinal)
04/2016
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
05/2014

Drug/Important Bio-Agent (IBA)

19quinolineIBA
05/2020 - 02/2005
8N-formyl-13-dihydrocarminomycin (NFD)IBA
02/2019 - 01/2010
5furanIBA
02/2014 - 01/2010
4Biological ProductsIBA
05/2020 - 01/2013
4Pharmaceutical PreparationsIBA
11/2018 - 01/2015
4OximesIBA
11/2013 - 08/2005
4DNA (Deoxyribonucleic Acid)IBA
04/2013 - 03/2008
4DiaminesIBA
09/2009 - 11/2006
3GlucuronidaseIBA
01/2022 - 11/2017
3trioctyl phosphine oxide (TOPO)IBA
02/2019 - 03/2010
3Irinotecan (Camptosar)FDA LinkGeneric
01/2019 - 12/2015
31- (4- (furo(2,3- b)quinolin- 4- ylamino)phenyl)ethanoneIBA
11/2018 - 12/2012
3Antineoplastic Agents (Antineoplastics)IBA
06/2015 - 11/2006
2CarcinogensIBA
01/2022 - 01/2021
29- methoxy- 6- (piperazin- 1- yl)- 11H- indeno(1,2- c)quinoline- 11- one O-3-(dimethylamino)propyl oximeIBA
08/2016 - 04/2013
2Type I DNA Topoisomerases (Topoisomerase I)IBA
08/2016 - 04/2013
2CamptothecinIBA
08/2016 - 08/2010
2ErbB Receptors (EGF Receptor)IBA
02/2013 - 06/2010
2NF-kappa B (NF-kB)IBA
09/2010 - 03/2010
2Proteins (Proteins, Gene)FDA Link
08/2010 - 09/2006
2QuinolinesIBA
03/2010 - 02/2008
1TransferasesIBA
01/2021
1Sarcosine (Methylglycine)IBA
01/2021
1CurcuminIBA
07/2020
1PhytochemicalsIBA
02/2019
1Type II DNA Topoisomerases (Topoisomerase II)IBA
02/2019
1Freund's AdjuvantIBA
01/2019
1AndrogensIBA
11/2018
1Docetaxel (Taxotere)FDA Link
11/2018
1Interleukin-8 (Interleukin 8)IBA
10/2018
1Interleukin-6 (Interleukin 6)IBA
10/2018
1Imiquimod (Aldara)FDA LinkGeneric
10/2018
1Thalidomide (Thalomid)FDA Link
10/2018
1EnzymesIBA
11/2017
1GlucuronidesIBA
11/2017
1Isoniazid (Ftivazide)FDA LinkGeneric
06/2017
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
01/2017
1QuinolonesIBA
04/2016
1Reactive Oxygen Species (Oxygen Radicals)IBA
04/2016
1Topotecan (Hycamtin)FDA LinkGeneric
12/2015
1AntioxidantsIBA
07/2015
1Antimitotic AgentsIBA
01/2015
12-furanylvinylquinolineIBA
01/2015
1Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
09/2014
1furano-1,2-naphthoquinoneIBA
05/2014
1CFS-1686IBA
01/2014
1Bromodeoxyuridine (BrdU)IBA
04/2013
1beta-lapachoneIBA
01/2013
1Matrix Metalloproteinase 2 (Gelatinase A)IBA
12/2012
1Matrix Metalloproteinases (MMPs)IBA
12/2012
1fosbretabulin (combretastatin A4)IBA
11/2012
1Prostaglandins EIBA
05/2012
1Estrogen ReceptorsIBA
01/2012
1p38 Mitogen-Activated Protein KinasesIBA
09/2010
1AminesIBA
08/2010
1HydrogenIBA
08/2010
1Histones (Histone)IBA
08/2010
1Cytotoxins (Cytolysins)IBA
08/2010
1PiperazineIBA
08/2010
1hydroxide ionIBA
08/2010
1Caspase 3 (Caspase-3)IBA
08/2010
1Epidermal Growth Factor (EGF)IBA
06/2010
1chloroacetaldehydeIBA
06/2010
1lawsoneIBA
06/2010
1Mitogen-Activated Protein KinasesIBA
09/2009
1imidazoleIBA
09/2009
1Dinoprostone (PGE2)FDA Link
09/2009

Therapy/Procedure

2Therapeutics
01/2021 - 11/2018
2Castration
11/2018 - 01/2015
2Oral Administration
11/2017 - 07/2011
1Chemoprevention
01/2022
1Drug Therapy (Chemotherapy)
01/2019